From Hanselminutes.com:
Hanselminutes is a weekly audio talk show with noted web developer and technologist Scott Hanselman and hosted by Carl Franklin. Scott discusses utilities and tools, gives practical how-to advice, and discusses ASP.NET or Windows issues and workarounds.

If I only had time for one podcast a week, this would be the one I listened to.  In fact, if I was stranded on a desert island and could only pick one thing to listen to … well it wouldn’t be this, but if I could somehow get weekly updates I would think about it.

Carl and Scott seem to hit on random topics every week, but it somehow seems to either be something I curious about or didn’t realize I needed to know.  They don’t waste your time with the 10 minutes of small talk upfront, and Scott used to end quite a few podcasts with the line “Hope we didn’t waste your time”, which seems to be one of the driving forces in the show.

Scott has a unique look at software and technology, and there is just something about it I enjoy.  He has a lifehacker-type approach to development and life in general, and is all about finding clever tools that will help him save time or simplify his life.  Bottom line, Scott is a likable guy that cuts the chase, has practical advice, doesn't include fluff, and I can’t remember him ever wasting my time.